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上海有机化学研究所 洪然 男 汉族 博导
 

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研究领域

 

天然产物(仿生)全合成,生物酶催化,不对称合成

 

招生信息

   
招生专业
070303-有机化学
招生方向
天然有机化学
天然有机化学

教育背景

   
学历
-- 研究生 
学位
-- 博士 
出国学习工作

​2001年8月—2002年6月博士后,UniversityofHouston(JayK.Kochi教授);

2002年7月—2007年3月博士后,BrandeisUniversity(LiDeng教授)

 

工作经历

2007年3月始 研究员,中国科学院上海有机化学研究所

 

工作简历
   
社会兼职
   

教授课程

   

专利与奖励

   
奖励信息
(1) ACP Lectureship (Japan), 其他, 2016
(2) ACP Lectureship (Malaysia), 其他, 2016
(3) ACP Lectrueship (Taiwan), 其他, 2015
专利成果
   

出版信息

39. Guoli He, Yan Wang, Calvine Lai, Wenhua Li, and Ran Hong*, "Stereoselective  construction of skipped polyol in polyketides enabled by oxonia-Cope  rearrangement and iodolactonization: Enantioselective synthesis of  (+)-yashabushitriol” Sci. China Chem. 201659, 1197-1204.

http://link.springer.com/article/10.1007/s11426-016-0073-3

38.  Lin Yang, Zuming Lin, Sha-Hua Huang*, and Ran Hong*, "Stereodivergent  Synthesis of Functionalized Tetrahydropyrans Accelerated by  Mechanism-Based Allylboration and Bioinspired oxa-Michael Cyclization"Angew. Chem. Int. Ed. 201655, 6280-6284.

http://onlinelibrary.wiley.com/doi/10.1002/anie.201600558/full

37. Lumin  Zhang, Lili Zhu, Jun Yang*, Jisheng Luo, and Ran Hong*,  "Stereoselective alpha-Hydroxylation of Amides with Oppolzer's Sultam as  Chiral Auxiliary" J. Org. Chem. 201681, 3890-3900.

http://pubs.acs.org/doi/abs/10.1021/acs.joc.6b00068

36. Wenhua  Li, Zuming Lin, Long Chen, Xuechao Tian, Sha-Hua Huang*, and Ran Hong*,  "Highly Stereoselective Kinetic Resolution of alpha-Allenic Alcohols:  An Enzymatic Approach" "Tetrahedron Lett. 2016,57, 603-606.

http://www.sciencedirect.com/science/article/pii/S004040391530513X

Highlighted as "Hot off the press" (Nat. Prod. Rep. 2016, doi:10.1039/c6np90012g)

35.  Sha-Hua Huang*, Xuechao Tian, Xianwei Mi, Yan Wang*, Ran  Hong, "Nitroso-ene Cyclization Enabled Access To 1-Azaspiro[4.4]nonane  and Its Application In a Modular Synthesis Toward (±)-Cephalotaxine" Tetrahedron Lett. 201556, 6656-6658DOI:10.1016/j.tetlet.2015.10.002

http://www.sciencedirect.com/science/article/pii/S0040403915301994

34. Hao Liu#, Jing Yu#, Xinyu Li, Rui Yan, Ji-Chang Xiao, and Ran Hong*, "Stereoselectivity in N-Iminium Ion Cyclization: Development of an Efficient Synthesis of (+/-)-Cephalotaxine" Org. Lett. 201517, 4444-4447. DOI: 10.1021/acs.orglett.5b02106. (These authors contributed equally to the work.)

http://pubs.acs.org/doi/abs/10.1021/acs.orglett.5b02106?src=recsys

33. Jie Ouyang#, Rui Yan#, Xianwei Mi, and Ran Hong*, "Enantioselective Total Synthesis of (−)-Hosieine A"Angew. Chem. Int. Ed. 201554, 10940-10943. DOI: 10.1002/anie.201505251(#These authors contributed equally to the work.)

http://onlinelibrary.wiley.com/doi/10.1002/anie.201505251/abstract

32. Kuan Zheng, Changmin Xie, and Ran Hong*, "Bioinspired Iterative Synthesis of Polyketides", Front. Chem.20153, e32.

http://journal.frontiersin.org/article/10.3389/fchem.2015.00032/abstract

31. Lili Zhu*, Sha-Hua Huang, Jing Yu, and Ran Hong*, "Constructive Innovation of Approaching Bicyclo[3.2.1]octane in ent-Kauranoids" (Digest paperTetrahedron Lett. 201556, 23-31. doi:10.1016/j.tetlet.2014.11.035

http://www.sciencedirect.com/science/article/pii/S0040403914019170

30.  Sha-Hua Huang*, Wenhua Li, Long Chen, Jian-He Xu, and Ran Hong*,  "Chemoenzymatic Construction of Chiral Alkenyl Acetylenic Alcohol: A Key  Building Block to Access Diastereoisomers of Polyacetylenes: "Bioresources and Bioprocessing 20152, e10.

http://www.bioresourcesbioprocessing.com/content/2/1/10

29. Sha-Hua Huang*, Meng-Yuan Huang, Xueshun Jia, and Ran Hong, "Chemistry and Biology of Bakuchiol"Chin. J. Org. Chem. 201434, 2412-2423.

http://sioc-journal.cn/Jwk_yjhx/CN/abstract/abstract344619.shtml

28. Lin Yang,# Guoli He,# Ruifeng Yin,# Lili Zhu, Xiaoxia Wang, and Ran Hong*, "Synthesis of Polyketide Stereoarrays Enabled by A Traceless Oxonia–Cope Rearrangement" Angew. Chem. Int. Ed. 201453, 11600-116004. (#These authors contributed equally to the work.)  DOI: 10.1002/anie.201407231.

http://onlinelibrary.wiley.com/doi/10.1002/anie.201407231/abstract

27. Meng-Yuan Huang, Long Chen, Ruoxi Li, Xueshun Jia*, and Ran Hong*, "Synthesis of rac-Bakuchiol via a Pot-Economy Approach" Chin. J. Chem. 201432, 715-720. (Dedicated to Professors Lixin Dai and Chengye Yuan on the Occasion of Their 90th Birthdays.)

http://onlinelibrary.wiley.com/doi/10.1002/cjoc.201400160/pdf

26.  Hua-Xing Huo, Jeremy R. Duvall, Meng-Yuan Huang, and Ran Hong*,  "Catalytic Asymmetric Allylation of Carbonyl Compounds and Imines with  Allyl Boronates" Org. Chem. Front. 20141, 303-320. doi:10.1039/C3QO00081H.

http://pubs.rsc.org/en/content/articlelanding/2014/qo/c3qo00081h#!divAbstract

25. Lili Zhu,# Chisheng Loh,#  and Ran Hong*, "Total Synthesis of (±)-Cafestol: A Late-Stage  Construction of the Furan Ring Inspired by A Biosynthesis Strategy" Org. Lett. 201416, 2162-2165. (#These authors contributed equally to the work.) (ACS Editor's Choice)

Open Acesshttp://pubs.acs.org/doi/full/10.1021/ol500623w

24. Changmin Xie,# Donghu Bai,#  Sha-Hua Huang, Xueshun Jia*, and Ran Hong*, "Kinetic Resolution of  Diols via Etherification Catalyzed by a Chiral Phosphoric Acid: Concise  Synthesis of (+)-Sacidumlignan D" Asian J. Org. Chem. 20143, 277-280. doi:10.1002/ajoc.201300250(#These authors contributed equally to the work.)(Editor's Choice)

http://onlinelibrary.wiley.com/doi/10.1002/ajoc.201300250/pdf

23. Huili  Liu, Kuan Zheng, Xiang Lu, Xiaoxia Wang*, and Ran Hong*, "Study on  Total Synthesis of Velbanamine: Chemoselective Dioxygenation of Alkenes  with PIFA via a Stop-and-Flow Strategy" Beilstein J. Org. Chem.20139, 983-990 (Invited for the Thematic Issue on Natural Product Synthesis).

http://www.beilstein-journals.org/bjoc/content/pdf/1860-5397-9-113.pdf

22Donghu Bai, Sha-Hua Huang*, Zuming Lin, Lin Yang, Junzeng Dai, Meng-Yuan Huang, Xueshun Jia*, and Ran Hong*, "Aza-Belluš-Claisen Rearrangement-Enabled Synthesis of Racemic Tapentadol and Its StereoisomersChin. J. Chem. 201331, 317-320 (selected as the Cover Paper) (Dedicated to Professor Guo-Qiang Lin on the occasion of his 70th Birthday).

21. Lili Zhu and Ran Hong*, "Biomimetic Cationic Cyclization toward ent–Kaurene-type Diterpenoids" Chin. J. Chem. 201331, 111-118 (Special Issue, Dedicated to the Memory of Professor Wei-Shan Zhou). 

20. Ran Hong, "Biomimetic Organic Synthesis" in Advances in Chemistry (China, 1982-2012), Sciences Press: Beijing; 2012, pp. 153-155. 

19. Yan Wang, Rob Hoen, and Ran Hong*, "Development of a Non-enzymatic Kinetic Resolution of α-Allenic Alcohols" Synlett 201223, 2729-2734 (doi:10.1055/s-0032-1317566) (Synpacts).

https://www.thieme-connect.com/ejournals/pdf/10.1055/s-0032-1317566.pdf

18. Xianwei Mi, Yan Wang, Lili Zhu, Ren-Xiao Wang, and Ran Hong*, "Enantioselective Synthesis of (-)-Stemoamide" Synthesis 201244, 3432-3440 (doi:10.1055/s-0032-1317499) (Feature article).

https://www.thieme-connect.com/ejournals/pdf/10.1055/s-0032-1317499.pdf

17. Sha-Hua Huang*, Huaxin Huo, Wenhua Li, and Ran Hong*, "Research Progress on Nitroso-ene Reaction"Chin. J. Org. Chem. 201232, 1776-1791.

16. Yan Wang, Kuan Zheng, and Ran Hong*, "Chiral Silver Phosphate-catalyzed Cycloisomeric Kinetic Resolution of alpha-Allenic Alcohols" J. Am. Chem. Soc. 2012134, 4096-4099.

(https://www.thieme-connect.com/ejournals/pdf/synfacts/doi/10.1055/s-0031-1291094.pdf)

15.  He Zhang, Chang-Bing Zhou, Qing-Yun Chen, Ji-Chang Xiao*, and Ran Hong*,  "Monofluorovinyl Tosylate: A Useful Building Block for the Synthesis of  Terminal Vinyl Monofluorides via Suzuki-Miyaura Coupling" Org. Lett.201113, 560-563.

(https://www.thieme-connect.com/ejournals/pdf/synfacts/doi/10.1055/s-0030-1259822.pdf and http://www.organic-chemistry.org/abstracts/lit3/158.shtm

14.  Yan Wang, Lili Zhu, Yuying Zhang, and Ran Hong*, "Bioinspired and Concise Synthesis of (+/-)-Stemoamide"Angew. Chem. 2011123, 2839-2842; Angew. Chem., Int. Ed. 201150, 2787-2790.

(https://www.thieme-connect.com/ejournals/pdf/synfacts/doi/10.1055/s-0030-1260373.pdf)

13.  Zhiyun Zhong, Ran Hong, and Xiaoxia Wang* "Construction of 3-Aryl-1,2,4-benzotriazines via Unprecedented Rearrangement of Bis(benzotrizaol-1-yl)methylarenes" Tetrahedron Lett. 201051, 6763-6766.

12.  Xinyu Li, Cheng Li, Wenjing Zhang, Shiqing Han, Xiang Lu, and Ran Hong* "Highly Stereoselective 7-Endo-Trig/Ring Contraction Cascade To Construct Pyrrolo[1,2-a]quinoline Derivatives" Org. Lett. 201012, 1696-1699.

11.  Cheng Li, Xinyu Li, and Ran Hong* “Synthetic Study on Tetrapetalones: Stereoselective Cyclization of N-acyliminium Ion To Construct Substituted 1-Benzazepines” Org. Lett. 200911, 4036-4039.

 

 


 

 

 

 
 
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